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E-cigarettes: Hazardous Or Helpful? Given that nicotine easily diffuses from the dermis to the bloodstream, acute nicotine publicity by e-liquid spilling (5 mL of a 20 mg/mL nicotine-containing refill is equivalent to 100 mg of nicotine) can easily be toxic and even lethal [8]. Thus, devices with rechargeable refills are one other problem of concern with e-cigarettes, particularly…

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